Recurrent Events Analysis in the Presence of Dependent Censoring: the Joint Frailty Model

Abstract: 'Recurrent Events Analysis in the Presence of Dependent Censoring: the Joint Frailty Model'

Many chronic diseases are characterised by non-fatal recurrent events. Examples of such include asthma attacks in asthma, epileptic seizures in epilepsy and hospitalisations for worsening condition in heart failure. Analysing all these repeat events within individuals is more representative of disease progression and more accurately estimates the effect of treatment on the true burden of disease. An increase in heart failure hospitalisations is associated with a worsening condition and a subsequent elevated risk of cardiovascular death, meaning that subjects may die during follow-up. A comparison of heart failure hospitalisation rates, between treatment groups, can be confounded by this competing risk of death and any analyses of recurrent events must take into consideration informative censoring that may be present. This presentation shall outline the different methods available for analysing recurrent events in the presence of dependent censoring and the relative merits of each method shall be discussed. In addition, data from multiple large-scale clinical trials in cardiovascular disease shall be used to illustrate the application of these methods. Future directions for recurrent events analysis shall also be considered.

About the speaker:

Prof Jennifer Rogers is Head of Statistical Research at specialist CRO, PHASTAR, and has broad portfolio of achievement, particularly in the development of clinical trial methodologies. She directs the research strategy at PHASTAR and provides leadership and advice to statistical consultancy activities. Jen is a highly active member of the Royal Statistical Society, currently sitting on Council and being the Society's Vice President for External Affairs. She was also appointed President of the British Science Association Mathematical Sciences Section for 2018 and was the London Mathematical Society Popular Lecturer for 2018. Jen can regularly be found talking all things statistics in schools, theatres and pubs, as well as the odd TV and radio appearance. She's made a few appearances on BBC Radio 4's More or Less and presented the popular "Best or Worst" segment on Series 42 of BBC's Watchdog Live in 2019.

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