Strengthening Causal Inference with Sensitivity Analyses: Using the Bayesian Parametric G-Formula

2 minute read

Published: February 19th, 2025

Understanding causal relationships in real-world data is challenging, particularly in observational studies, where confounding can introduce bias. If confounding is not properly accounted for, treatment effect estimates may be misleading, impacting decision-making.

Therefore, correctly modelling confounding is essential for valid causal inferences. Two popular approaches to achieve this are inverse probability of treatment weighting (IPTW) and the parametric g-formula. Both methods assume confounding has been adequately modelled. However, what if it is not?

Historically, this is listed as a limitation. In recent years, sensitivity analyses have become increasingly popular to better understand this assumption. This webinar will focus on using the Bayesian parametric g-formula as a sensitivity analysis for measured confounding. Prior information about confounders can be incorporated into the model. This allows for a better understanding of the range of the plausible effects. Various scenarios can also be considered including if the confounder is a weak confounder or strong confounder.

This approach offers a practical solution for researchers to ensure the validity of findings.

Learning Points:

  • How Bayesian methods improve sensitivity analyses
  • Incorporating prior knowledge about confounding
  • Practical applications for real-world data research

Watch this webinar recording and explore how the Bayesian Parametric G-Formula can be used as a sensitivity analysis tool to strengthen causal inference and improve the validity of findings.

Complete the form below to access the recording and slides.

Related articles

From Data to Decisions: TMLE, Doubly Robust Methods, and Federated Learning

From Data to Decisions: TMLE, Doubly Robust Methods, and Federated Learning

April 13th, 2026 1 minute read

This webinar will cover methods that are crucial to making informed decisions. Specifically, personalized care throug...

Causal Inference in Real World Evidence: What is it? Why now?

Causal Inference in Real World Evidence: What is it? Why now?

January 22nd, 2026 1 minute read

Causal inference is increasingly used to generate real-world evidence (RWE), by regulatory&n...

Regulatory-Grade Use of External Data: Bayesian Borrowing, Hybrid Trials and External Controls 

Regulatory-Grade Use of External Data: Bayesian Borrowing, Hybrid Trials and External Controls 

November 20th, 2025 1 minute read

Use of external data to augment clinical trials has been increasingly evaluated and is transforming drug development ...